Functions of IL-4 and control of its expression (2024)

Brown, M. A., & Hural, J. (1997). Functions of IL-4 and control of its expression. Critical reviews in immunology, 17(1), 1-32. https://doi.org/10.1615/critrevimmunol.v17.i1.10

Brown, Melissa A. ; Hural, John. / Functions of IL-4 and control of its expression. In: Critical reviews in immunology. 1997 ; Vol. 17, No. 1. pp. 1-32.

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title = "Functions of IL-4 and control of its expression",

abstract = "IL-4 has been called the 'prototypic immunoregulatory cytokine.' Like many cytokines, it can affect a variety of target cells in multiple ways. IL- 4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FcεRI+ mast cells and basophils. Based on the different tissue distribution and access to distinct target cells, IL-4 derived from T and FcεRI+ cells may have quite different effects on these immunological processes. In view of this, as well as the clear correlation of aberrant expression with disease, it is of interest to understand the signals that regulate IL-4 expression in a cell-specific manner. Recently, progress has been made in defining the T-cell- and FcεRI-receptor-mediated signals that stimulate IL-4 gene expression. These studies have demonstrated that there are common and cell-specific signaling pathways that regulate production of this cytokine. In this review, we summarize the activities of IL-4 defined both in vitro and in vivo and compare the signals leading to IL-4 expression in cells of both T- and mast-cell lineage.",

keywords = "IL-4, NF-AT, T cells, TCR- and FceRI-mediated signaling mechanisms, basophils, mast cells, transcriptional regulation",

author = "Brown, {Melissa A.} and John Hural",

year = "1997",

doi = "10.1615/critrevimmunol.v17.i1.10",

language = "English (US)",

volume = "17",

pages = "1--32",

journal = "Critical reviews in immunology",

issn = "1040-8401",

publisher = "Begell House Inc.",

number = "1",

}

Brown, MA & Hural, J 1997, 'Functions of IL-4 and control of its expression', Critical reviews in immunology, vol. 17, no. 1, pp. 1-32. https://doi.org/10.1615/critrevimmunol.v17.i1.10

Functions of IL-4 and control of its expression. / Brown, Melissa A.; Hural, John.
In: Critical reviews in immunology, Vol. 17, No. 1, 1997, p. 1-32.

Research output: Contribution to journal › Article › peer-review

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T1 - Functions of IL-4 and control of its expression

AU - Brown, Melissa A.

AU - Hural, John

PY - 1997

Y1 - 1997

N2 - IL-4 has been called the 'prototypic immunoregulatory cytokine.' Like many cytokines, it can affect a variety of target cells in multiple ways. IL- 4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FcεRI+ mast cells and basophils. Based on the different tissue distribution and access to distinct target cells, IL-4 derived from T and FcεRI+ cells may have quite different effects on these immunological processes. In view of this, as well as the clear correlation of aberrant expression with disease, it is of interest to understand the signals that regulate IL-4 expression in a cell-specific manner. Recently, progress has been made in defining the T-cell- and FcεRI-receptor-mediated signals that stimulate IL-4 gene expression. These studies have demonstrated that there are common and cell-specific signaling pathways that regulate production of this cytokine. In this review, we summarize the activities of IL-4 defined both in vitro and in vivo and compare the signals leading to IL-4 expression in cells of both T- and mast-cell lineage.

AB - IL-4 has been called the 'prototypic immunoregulatory cytokine.' Like many cytokines, it can affect a variety of target cells in multiple ways. IL- 4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FcεRI+ mast cells and basophils. Based on the different tissue distribution and access to distinct target cells, IL-4 derived from T and FcεRI+ cells may have quite different effects on these immunological processes. In view of this, as well as the clear correlation of aberrant expression with disease, it is of interest to understand the signals that regulate IL-4 expression in a cell-specific manner. Recently, progress has been made in defining the T-cell- and FcεRI-receptor-mediated signals that stimulate IL-4 gene expression. These studies have demonstrated that there are common and cell-specific signaling pathways that regulate production of this cytokine. In this review, we summarize the activities of IL-4 defined both in vitro and in vivo and compare the signals leading to IL-4 expression in cells of both T- and mast-cell lineage.

KW - IL-4

KW - NF-AT

KW - T cells

KW - TCR- and FceRI-mediated signaling mechanisms

KW - basophils

KW - mast cells

KW - transcriptional regulation

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Brown MA, Hural J. Functions of IL-4 and control of its expression. Critical reviews in immunology. 1997;17(1):1-32. doi: 10.1615/critrevimmunol.v17.i1.10