Functions of IL-4 and control of its expression (2024)

Brown, M. A., & Hural, J. (2017). Functions of IL-4 and control of its expression. Critical reviews in immunology, 37(2-6), 181-212. https://doi.org/10.1615/CritRevImmunol.v37.i2-6.30

Brown, Melissa Ann ; Hural, John. / Functions of IL-4 and control of its expression. In: Critical reviews in immunology. 2017 ; Vol. 37, No. 2-6. pp. 181-212.

@article{f4f20e9ef1934f55b4b8934c423cbc0a,

title = "Functions of IL-4 and control of its expression",

abstract = "IL-4 has been called the “prototypie immunoregulatory cytokine.” Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FceRl+ mast cells and basophils. Based on the different tissue distribution and access to distinct target cells, IL-4 derived from T and FceRl+ cells may have quite different effects on these immunological processes. In view of this, as well as the clear correlation of aberrant expression with disease, it is of interest to understand the signals that regulate IL-4 expression in a cell-specific manner. Recently, progress has been made in defining the T-cell- and FcεRl-receptor-mediated signals that stimulate IL-4 gene expression. These studies have demonstrated that there are common and cell-specific signaling pathways that regulate production of this cytokine. In this review, we summarize the activities of IL-4 defined both in vitro and in vivo and compare the signals leading to IL-4 expression in cells of both T- and mast-cell lineage.",

keywords = "Basophils, IL-4, Mast cells, NF-AT, T cells, TCR- and FceRI-mediated signaling mechanisms, Transcriptional regulation",

author = "Brown, {Melissa Ann} and John Hural",

note = "Funding Information: We thank Dr. Melanie Sherman for critically reading this manuscript. The studies in our laboratory were supported by the Medical Research Foundation of Oregon and by National Institutes of Health grants CA47992 and AI34040. Melissa A. Brown is a scholar of the Leukemia Society of America.",

year = "2017",

doi = "10.1615/CritRevImmunol.v37.i2-6.30",

language = "English (US)",

volume = "37",

pages = "181--212",

journal = "Critical reviews in immunology",

issn = "1040-8401",

publisher = "Begell House Inc.",

number = "2-6",

}

Brown, MA & Hural, J 2017, 'Functions of IL-4 and control of its expression', Critical reviews in immunology, vol. 37, no. 2-6, pp. 181-212. https://doi.org/10.1615/CritRevImmunol.v37.i2-6.30

Functions of IL-4 and control of its expression. / Brown, Melissa Ann; Hural, John.
In: Critical reviews in immunology, Vol. 37, No. 2-6, 2017, p. 181-212.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Functions of IL-4 and control of its expression

AU - Brown, Melissa Ann

AU - Hural, John

N1 - Funding Information:We thank Dr. Melanie Sherman for critically reading this manuscript. The studies in our laboratory were supported by the Medical Research Foundation of Oregon and by National Institutes of Health grants CA47992 and AI34040. Melissa A. Brown is a scholar of the Leukemia Society of America.

PY - 2017

Y1 - 2017

N2 - IL-4 has been called the “prototypie immunoregulatory cytokine.” Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FceRl+ mast cells and basophils. Based on the different tissue distribution and access to distinct target cells, IL-4 derived from T and FceRl+ cells may have quite different effects on these immunological processes. In view of this, as well as the clear correlation of aberrant expression with disease, it is of interest to understand the signals that regulate IL-4 expression in a cell-specific manner. Recently, progress has been made in defining the T-cell- and FcεRl-receptor-mediated signals that stimulate IL-4 gene expression. These studies have demonstrated that there are common and cell-specific signaling pathways that regulate production of this cytokine. In this review, we summarize the activities of IL-4 defined both in vitro and in vivo and compare the signals leading to IL-4 expression in cells of both T- and mast-cell lineage.

AB - IL-4 has been called the “prototypie immunoregulatory cytokine.” Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produced only by a subset of activated hematopoietic cells, including T cells and FceRl+ mast cells and basophils. Based on the different tissue distribution and access to distinct target cells, IL-4 derived from T and FceRl+ cells may have quite different effects on these immunological processes. In view of this, as well as the clear correlation of aberrant expression with disease, it is of interest to understand the signals that regulate IL-4 expression in a cell-specific manner. Recently, progress has been made in defining the T-cell- and FcεRl-receptor-mediated signals that stimulate IL-4 gene expression. These studies have demonstrated that there are common and cell-specific signaling pathways that regulate production of this cytokine. In this review, we summarize the activities of IL-4 defined both in vitro and in vivo and compare the signals leading to IL-4 expression in cells of both T- and mast-cell lineage.

KW - Basophils

KW - IL-4

KW - Mast cells

KW - NF-AT

KW - T cells

KW - TCR- and FceRI-mediated signaling mechanisms

KW - Transcriptional regulation

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DO - 10.1615/CritRevImmunol.v37.i2-6.30

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SN - 1040-8401

VL - 37

SP - 181

EP - 212

JO - Critical reviews in immunology

JF - Critical reviews in immunology

IS - 2-6

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Brown MA, Hural J. Functions of IL-4 and control of its expression. Critical reviews in immunology. 2017;37(2-6):181-212. doi: 10.1615/CritRevImmunol.v37.i2-6.30